Case studies from human and veterinary medicine

The plasma care uses cold atmospheric plasma to inactivate wound pathogens including multi-drug resistant organisms. Based on current knowledge treatment with the plasma care is painless and free of side effects and/or allergic reactions.

The plasma care is used for the treatment of wounds with different origins, for example post-operative wound healing disorders, diabtic foot syndrome and leg ulcers. Here a some examples.



Example:
post-operative wound healing disorder

 

Initial situation:

Patient (63 years old, female): traumatic lower leg amputation, post-operative wound healing disorder at the stump (contact surface of the prosthesis) following skin flap surgery, wound present for 1.5 years, no infection.

Image documentation:

Treatment overview:

9 treatments (1 min / 13 cm²) carried out within three and a half weeks. Reduction of wound size from 2.04 cm x 1.87 cm to 0.48 cm x 0.51 cm

Example:
post-operative wound healing disorder

 

Initial Situation: 

Patient (40 years old, male): Surgical removal of a sternal liposarcoma with partial resection of the ribs C2-5 on the right and C2-4 on the left. Post-operative wound healing disorder with sternal putrid wound abscess cavity, no improvement after wound revision and application of an NPWT wound sealing system, formation of necrotic tissue. 

Image documentation:  

Treatment overview:

Treatment for 13 weeks, on average 3 treatments / week.

Over the course of the treatment the crusts and necroses were removed regularly, necrosis spots became visibly smaller, the wound became flatter and closed from below and from the edges.

Example:
post-operative wound healing disorder

 

Initial situation: 

Patient (77 years old, female): secondary wound closure intention (split-thickness skin graft and skin flap) after trauma (contusion in a car accident). Wound healing disorder with known CVI and cardiac insufficiency, infection with Enterobacter aerogenes, tendency to form edema in the lower legs.

Image documentation:  

Treatment overview:

Cold plasma treatments 2 x per week  (1 min) and switch to moist wound care to soften crusts and necroses, in addition to regular mechanical debridement. After 18 treatments in 11 weeks the wound was fully epithelialized except for punctiform superficial skin openings (wound size: 0.22 x 0.17 cm). Plasma therapy is no longer necessary.

Example:
Pressure ulcer

 

Initial situation:

Patient (64 years old, female): post-polio syndrome, chronic respiratory and ventilatory insufficiency, morbidly obese (grade III). Hypergranulating pressure ulcer on the nape of the neck was caused by friction and moisture on the belt of the ventilation mask, stagnation in the granulation phase. Patient fell into hypercapnic coma. Ulcer was treated after tracheotomy.

Image documentation:  

Treatment overview:

7 cold plasma treatments (6 x 2 min, 1 x 1 min) in 3 weeks, the first treatments were carried out on consecutive days. The wound was fully epithelialized after 22 days. 

Example:
diabetic foot syndrome

 

Initial situation: 

Patient (50 years old, male): Type II diabetes mellitus, diabetic foot syndrome; border zone amputation of the 4th toe on the left foot. Wound infection with partially resistant corynebacteria, enterococci and staphylococci.

Image documentation:

Treatment overview:

2 CAP treatments / week in the first 3 weeks, then 1 treatment every 2 – 4 weeks (9 treatments in 12 weeks) as part of the dressing change in the clinic; healing progressed upon start of plasma therapy as adjunct to optimal wound treatment with surgical debridement, pressure relief, suitable wound dressing, and others.

Example:
Ulcus cruris

 

Initial situation: 

Patient (77 years old, female): Bed-ridden due to a spinal cord injury. Recurrence of a leg ulcer of unclear origin on the right lower leg, no edema, state of vascular system unclear. Wound healing stagnated for several months, occasionally purulent deposits, patient reported severe pain during mechanical wound debridement. 

Image documentation:  

Treatment overview:

8 cold plasma treatments (1 min) in 4 weeks led to a significant reduction in wound size, ongoing epithelialization and a reduction in pain; upon interruption of CAP treatment the ulcer recurred; cold plasma treatment according to the previous regimen (twice per week, 1 min) was resumed and complete epithelialization of the wound was achieved after 4 weeks.

Veterinary medicine
example:
Bacterial infection of
surgical wound

 

Initial situation:

Paint horse mare (8 years old): after palmar nerve neurectomy the mare developed neuromas at both nerve endings, the wound was infected with E. coli (partially resistant to antibiotics) and a post-operative wound healing disorder developed; upon removal of the neuromas in a second operation, edematous and necrotic tissue was observed in the wound and resected, no improvement in wound situation.

Image documentation:  

Treatment overview:

Treatment period of 19 days: 7 days – 2 days interruption – 7 days (2 min CAP/wound area). The antibiosis was discontinued after 11 days, the wound was fully epithelialized after 19 days.