Cold atmospheric plasma in medical technology

The plasma care® has been approved as a medical product since 2019 and is used in clinical routine. Over 30.000 successful treatments have already been carried out with the mobile plasma care®. The plasma care® inactivates bacteria including multi-resistant pathogens, viruses, fungi and spores and supports wound healing.


The majority takeover of terraplasma medical GmbH by Viromed Plasma GmbH, a member of the Viromed Group, was announced today.

9th December 2021 Garching – The majority takeover of terraplasma medical GmbH by Viromed Plasma GmbH, a member of the Viromed Group, was announced today. terraplasma GmbH will continue to hold shares in terraplasma medical GmbH in order to contribute its expertise in the field of cold atmospheric plasmas in the future. The common goal of Viromed and terraplasma is to establish as the world’s leading company and innovation leader for medical devices using cold atmospheric plasma in a wide range of medical applications.

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 “Dermatologic Therapy” 08_2021

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What is cold atmospheric plasma?

The fourth aggregate state is called plasma, which arises from the supply of energy to gas.

Cold atmospheric plasma (CAP) is a partially ionized room temperature gas. It consists of a reactive mix of electrons, ions, excited atoms and molecules, reactive species (such as O3, NO, NO2, etc.), UV-radiation, electromagnetic fields and heat. It interacts with bacteria, viruses and fungi, to inactivate the microorganisms. Human eukaryotic cells however are safe from the effects of temporarily applied CAP, due to additional protective measures. So far no tissue damage due to treatment with the plasma care® is known.

Use of cold plasma in medical technology


This is how cold plasma affects microorganisms

The reactive species generated by plasma can interact with cells in different ways. The effects are physical (e.g. recombination or excitation of excited molecules/atoms at the surface) or chemical (e.g. hydrogen denaturation by interaction of hydroxyl radicals). In prokaryotic cells, this directly results in destruction of cellular macromolecules, including DNA, and the microorganism is inactivated. On the other hand human eukaryotic cells are much better protected and thus are not damaged by the plasma care® treatment.

The patient is neither exposed to radiation nor does electricity flow through the skin. You can find more about plasma technology under “Technology”

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This is how cold plasma affects human cells

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Human cells are protected against the effects of plasma due to the cell nucleus and the cellular repair mechanisms. It was observed in-vitro that the oxidative stress caused by the cold plasma stimulates cell biological survival mechanisms. This is one possible explanation for the improved wound healing seen on some patients.

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