Cold Atmospheric Plasma Promotes the Immunoreactivity of Granulocytes In Vitro
Kupke LS, Arndt S, Lenzer S, Metz S, Unger P, Zimmermann JL, Bosserhoff AK, Gruber M, Karrer S. Cold Atmospheric Plasma Promotes the Immunoreactivity of Granulocytes In Vitro. Biomolecules. 2021 Jun 17;11(6):902. doi: 10.3390/biom11060902. PMID: 34204360; PMCID: PMC8235417.
The cell biological results of the study on the mouse model show that the change in immunoreactivity could be an important supporting mechanism for the CAP-induced improvement in wound healing.
Cold atmospheric plasma (CAP) reduces bacteria and interacts with tissues and cells, thus improving wound healing. The CAP-related induction of neutrophils was recently described in stained sections of wound tissue in mice. Consequently, this study aimed to examine the functionality of human polymorphonuclear cells (PMN)/granulocytes through either a plasma-treated solution (PTS) or the direct CAP treatment with different plasma modes and treatment durations. In conclusion, the modification of PMN immunoreactivity may be a main supporting mechanism for CAP-induced improvement in wound healing.
