Handheld
The hightech Handheld
For the treatment of skin diseases - mobile. simple. effective.
Ohne ist mehr
„Less is more“:
Dermatological therapies for bacterial and fungal skin diseases without antibiotics and cortisone.
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The hightech handheld

With the size and weight of a telephone handset, the plasma derma care® in conjunction with the spacer is a mobile, CE-certified medical device that generates cold atmospheric plasma from the ambient air. CAP inactivates bacteria and human pathogenic fungi highly efficiently – regardless of the type and level of resistance to antibiotics.

In addition, there is the healing effect: CAP therapy has an antipruritic effect and promotes cell regeneration (cell division) of healthy skin cells by activating local immune processes. The treatment is valued as painless.

In Germany plasma treatment has been part of the specialist training in dermatology since 2021

Skin-friendly and flexible: The biocompatible foam attachment of the plasma derma care® ensures a high cold plasma density even on uneven skin areas and areas on the face.

Indication areas in dermatology

The diverse mechanism of action of cold plasma enables the treatment of a large number of dermatological diseases:

What is cold plasma and what can it do?

In order to generate KAP, a gas is supplied with just enough energy that it is only partially ionized, i.e. only one particle of 10⁹ is ionized. This allows the temperature to be controlled so that it remains below 40°C.

Read more about “What is cold plasma?”

Hautzellen

How does cold plasma affect skin cells?

The effect is quite different in healthy human cells. In them, survival mechanisms are stimulated by the reactive species and cell division is stimulated.
Pilze

How does cold plasma affect fungi?

Most fungal infections are difficult to treat because fungi and spores have very resistant structures. Treatment with CAP deforms spores of fungi, which leads to breaking, flattening and shrinkage.
Orange colored multiple antibiotic resistant Pseudomonas aeruginosa bacterium - 3d illustration

How does cold plasma affect bacteria?

If the CAP encounters bacteria or multidrug-resistant pathogens (MRE) with a high proportion of reactive species, the cellular structures including dna are destroyed and the bacterium inactivated.

Wie wirkt Kaltplasma auf Bakterien?

Wie wirkt Kaltplasma auf Bakterien?

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Wie wirkt Kaltplasma auf Hautzellen?

Wie wirkt Kaltplasma auf Hautzellen?

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Wie wirkt Kaltplasma auf Pilze?

Wie wirkt Kaltplasma auf Pilze?

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Trifft das Kaltplasma mit einem hohen Anteil an reaktiven Spezies auf Bakterien oder auch multiresistenter Erreger (MRE), dann werden bei diesen die zellulären Strukturen (Denaturierung von Proteinen, Inaktivierung von Enzymen) einschließlich der DNA zerstört und das Bakterium eliminiert.

Ganz anders stellt sich die Wirkung bei gesunden menschlichen Zellen dar. In ihnen werden durch die reaktiven Spezies Überlebensmechanismen stimuliert und die Zellteilung angeregt.

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Die meisten Pilzinfektionen sind nur schwer zu behandeln, da Pilze und Sporen sehr widerstandsfähige Strukturen aufweisen. Durch die Behandlung mit CAP werden Sporen von Pilzen verformt, was zum Aufbrechen, zur Abflachung und Schrumpfung führt.

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How is plasma care® used?

For larger treatment areas, the treatment can be carried out up to 6 times within 10 minutes with a spacer.

Places in the immediate vicinity of the eyes as well as mouth and nose openings should be treated with special care. The CAP should not get into the respiratory tract or directly into the eyes of the patient; if necessary, aids such as nasal plugs and goggles can be used for this purpose. 

Case report from dermatology

Diagnosis: Congestive eczema
Concomitant disease: Varicosis

Patient: female, 56 years

Duration of the disease: 2 months

Beginning: Wound reddish and raised

End: Wound is closed

Therapy: 4 x treatments + homeopathic medicines

Diagnosis: Acne

Patient: female, 27 years

Duration of illness: acne has existed for several years

Beginning: red, purulent pustules

End: Pustules heal, no new ones have formed, less redness of the skin

Therapy: 4 treatments without prior cleansing = > decrease in redness

Publications on the use of CAP by indication area

Die Anwendung von KAP bei Akne wurde in Fallberichten und Studien untersucht:

Mariachiara, Dr. A. et al. Cold atmospheric plasma (CAP) as a promising therapeutic option for mild to moderate acne vulgaris: Clinical and non-invasive evaluation of two cases. Clin. Plasma Med. 100110 (2020) doi:10.1016/j.cpme.2020.100110.

Potter, M. J. et al. Facial acne and fine lines: transforming patient outcomes with plasma skin regeneration. Ann. Plast. Surg. 58, 608–613 (2007).

Lan, T., Xiao, Y., Tang, L., Hamblin, M. R. & Yin, R. Treatment of atrophic acne scarring with fractional micro-plasma radio-frequency in Chinese patients: A prospective study. Lasers Surg. Med. 50, 844–850 (2018).

Karrer, S. et al. Atmospheric Plasma in the Treatment of Acne Vulgaris. Appl. Sci. 11, (2021).

Die Anwendung von KAP bei Akne wurde in Fallberichten und Studien untersucht:

Mariachiara, Dr. A. et al. Cold atmospheric plasma (CAP) as a promising therapeutic option for mild to moderate acne vulgaris: Clinical and non-invasive evaluation of two cases. Clin. Plasma Med. 100110 (2020) doi:10.1016/j.cpme.2020.100110.

Potter, M. J. et al. Facial acne and fine lines: transforming patient outcomes with plasma skin regeneration. Ann. Plast. Surg. 58, 608–613 (2007).

Lan, T., Xiao, Y., Tang, L., Hamblin, M. R. & Yin, R. Treatment of atrophic acne scarring with fractional micro-plasma radio-frequency in Chinese patients: A prospective study. Lasers Surg. Med. 50, 844–850 (2018).

Karrer, S. et al. Atmospheric Plasma in the Treatment of Acne Vulgaris. Appl. Sci. 11, (2021).

Der Effekt vonKAP basiert neben der heilungsfördernden Wirkung auch darauf, dass es Bakterien und Pilze zuverlässig inaktiviert:

Terabe, Y., Kaneko, N. & Ando, H. Treating hard-to-heal skin and nail onychomycosis of diabetic foot with plasma therapy. Dermatol. Ther. 34, e15127 (2021).

Gnat, S. et al. Cold atmospheric pressure plasma (CAPP) as a new alternative treatment method for onychomycosis caused by Trichophyton verrucosum: in vitro studies. Infection 49, 1233–1240 (2021).

Borges, A. C. et al. Cold Atmospheric Pressure Plasma Jet Reduces Trichophyton rubrum Adherence and Infection Capacity. Mycopathologia 184, 585–595 (2019).

Boxhammer, V. et al. Investigation of the mutagenic potential of cold atmospheric plasma at bactericidal dosages. Mutat. Res. 753, 23–28 (2013).

Heinlin, J. et al. Contact-free inactivation of Trichophyton rubrum and Microsporum canis by cold atmospheric plasma treatment. Future Microbiol. 8, 1097–1106 (2013).

Klämpfl, T. G. et al. Decontamination of Nosocomial Bacteria Including Clostridium difficile Spores on Dry Inanimate Surface by Cold Atmospheric Plasma. Plasma Process. Polym. 11, 974–984 (2014).

Daeschlein, G. et al. Skin and wound decontamination of multidrug-resistant bacteria by cold atmospheric plasma coagulation. J. Dtsch. Dermatol. Ges. J. Ger. Soc. Dermatol. JDDG 13, 143–150 (2015).

Zimmermann, J. L. et al. Test for bacterial resistance build-up against plasma treatment. New J. Phys. 14, 073037 (2012).

Verschiedene weitere Erkrankungen, wie z.B.  atopische Dermatitis und Psoriasis, können sowohl im Tiermodell als auch in ersten Fallberichten von KAP profitieren.

Gan, L. et al. Medical applications of nonthermal atmospheric pressure plasma in dermatology: Applications of nonthermal plasma in cutaneous diseases. JDDG J. Dtsch. Dermatol. Ges. 16, 7–13 (2018).

Kim, Y. J. et al. Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis. Sci. Rep. 11, 14461 (2021).

Moon, I. J. et al. Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model. Sci. Rep. 11, 16091 (2021).

Gan, L. et al. Cold atmospheric plasma ameliorates imiquimod-induced psoriasiform dermatitis in mice by mediating antiproliferative effects. Free Radic. Res. 53, 269–280 (2019).

Lee, Y. S., Lee, M.-H., Kim, H.-J., Won, H.-R. & Kim, C.-H. Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression. Sci. Rep. 7, (2017).

Gareri, C., Bennardo, L. & De Masi, G. Use of a new cold plasma tool for psoriasis treatment: A case report. SAGE Open Med. Case Rep. 8, 2050313X20922709 (2020).

Daten in Vorbereitung

Neben bakteriellen und Pilzerkrankungen gibt es Hinweise auf die Wirksamkeit von KAP gegen Viren:

Bunz, O. et al. Cold atmospheric plasma as antiviral therapy – effect on human herpes simplex virus type 1. J. Gen. Virol. 101, 208–215 (2020).

Isbary, G. et al. Randomized placebo-controlled clinical trial showed cold atmospheric argon plasma relieved acute pain and accelerated healing in herpes zoster. Clin. Plasma Med. 2, 50–55 (2014).

Zimmermann, J. L. et al. Effects of cold atmospheric plasmas on adenoviruses in solution. in 2012 Abstracts IEEE International Conference on Plasma Science 2E-7-2E – 7 (IEEE, 2012). doi:10.1109/PLASMA.2012.6383555.

Ahlfeld, B. et al. Inactivation of a Foodborne Norovirus Outbreak Strain with Nonthermal Atmospheric Pressure Plasma. mBio 6, (2015).

Erste Publikationen zeigen sogar den inaktivierenden Effekt von Plasma auf Sars Cov-2 Vieren:

Chen, Z., Garcia, G., Arumugaswami, V. & Wirz, R. E. Cold plasma for SARS-CoV-2 Inactivation. http://medrxiv.org/lookup/doi/10.1101/2020.09.17.20192872 (2020) doi:10.1101/2020.09.17.20192872.

Cortázar, O. D., Megía-Macías, A., Moreno, S., Brun, A. & Gómez-Casado, E. Vulnerability of SARS-CoV-2 and PR8 H1N1 virus to cold atmospheric plasma activated media. Sci. Rep. 12, 263 (2022).

Qin, H. et al. Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage. J. Hazard. Mater. 430, 128414 (2022).

Jin, T. et al. Cold atmospheric plasma: A non-negligible strategy for viral RNA inactivation to prevent SARS-CoV-2 environmental transmission. AIP Adv. 11, 085019 (2021).

Die Wirkung von KAP auf Phlegmone konnte ebenfalls gezeigt werden:

Kalghatgi, S. et al. Applications of Non Thermal Atmospheric Pressure Plasma in Medicine. in Plasma Assisted Decontamination of Biological and Chemical Agents (eds. Güçeri, S.,

Fridman, A., Gibson, K. & Haas, C.) 173–181 (Springer Netherlands, 2008). doi:10.1007/>978-1-4020-8439-3_15.

Fridman, G. et al. Applied Plasma Medicine. Plasma Process. Polym. 5, 503–533 (2008).

ContaCt & FAQ

Questions about cold plasma therapy

There are many questions about cold plasma therapy: Which bacterie does cold plasma affect? How long does the therapy last? We have compiled the most frequently aske questions and answers for you here. You are also welcome to contact us directly.